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Amyotrophic Lateral Sclerosis

AKA: Lou Gehrig’s Disease

This disease is a degenerative, neurological disease that attacks the central nervous system, which includes the brain and the spinal cord.  The cause of ALS is not fully understood but some research would point to a few origins including gene mutation, unusual immune responses and even chemical imbalance. Smoking or toxic environmental exposure may cause ALS symptoms to begin. The symptoms of ALS include fine and gross motor skill issues such as difficulty with walking, muscle weakness, difficulty swallowing and increased risk of falling. ALS does not have a known cure.  

How can Medical Marijuana Help Patients with ALS?

Clinical evidence presented in 2004, 2010, and 2015 have shown that medical marijuana can reduce symptoms of ALS by stimulating appetite, reducing pain and relaxing muscles. In addition, the 2010 study showed Medical Marijuana to be a powerful antioxidant with anti-inflammatory effects. This means that it has neuroprotective results and may even prolong neuronal cell life span. 

Autism

Autism is an extensive developmental disorder that is expressed in almost all dimensions of the child’s development.

Autistic Spectrum Disorder (ASD) makes social interaction and communication difficult, and is marked by restricted and repetitive behavior. The range and severity of symptoms can vary widely and include difficulty with communication and social interactions, obsessive interests, and repetitive behaviors. Numerous studies have shown cannabis can relieve some of the symptoms suffered by many autistic people, including seizures, restlessness, and rage attacks.

How Medical Marijuana Helps Patients with Autism?

CBD is thought to be anti-inflammatory and has the potential to treat epilepsy, autism and psychiatric disorders without intoxicating side effects. Some published research suggests cannabis can alleviate spasticity and general pain in adults. Doctors have also begun to recommend CBD for children for Tourette syndrome, epilepsy, dystonia, and seizures.

Cancer

Cancer can come in many forms and is characterized by abnormal cells developing and dividing in an uncontrolled manner in the human body.  Cancer can form almost anywhere in the body.  Cancer cells are invasive and continue to divide and increase in number.  Cancer can cause many symptoms from pain to changes in weight and fatigue.  Gene mutations are the cause of cancer.  Your family history and environmental factors will affect your chances of developing cancer. While some cancers can be cured, others can be fatal. Early detection and treatment can greatly improve a patient’s survival rate.

How can Medical Marijuana Help Patients with Cancer?

Studies in 2015 and 2016 found that CBD (a major chemical compound in Medical Marijuana) demonstrated an ability to inhibit the growth of tumor cells in animals. Medical marijuana is very effective at treating symptoms of cancer including alleviating fatigue, pain, appetite loss, nausea, vomiting and anxiety.  Furthermore, a 2012 study published in PubMed showed that conventional cancer treatment combined with cannabinoids (Chemical compounds in Medical Marijuana) had a synergistic effect against cancer and tumor cells.  This means that by combining conventional treatment with Medical Marijuana, patients may benefit more than from just conventional treatment alone. 

Epilepsy and Seizure disorders

Epilepsy is a seizure disorder – the severity of the condition can vary.

Epilepsy is a seizure disorder; the severity of the condition can vary from patient to patient.  A seizure occurs in a patient when the body experiences an abnormal electrical storm in the brain.  This electrical storm causes the individual to experience changes in consciousness and sensation.  It manifests outwardly in a number of different ways including small eye flickers on the mild end to full body convulsions on the more severe end. 

How can Medical Marijuana Help Patients with Epilepsy and Seizure disorders?

THC and CBD, cannabinoids abundant in marijuana, exert their effects on both central and peripheral nervous systems. CBD specifically has shown promise in early research studies to have anti-seizure potential.   

Multiple Sclerosis

A degenerative disease of the central nervous system

Multiple Sclerosis (MS) is a degenerative disease of the central nervous system affecting the brain, spinal cord, and nerves. Symptoms of MS vary in range from a single symptom to multiple symptoms and mild in intensity to severe. Symptoms can include pain, fatigue, muscle stiffness or spasms, tremors, inflammation, depression, loss of muscle coordination or bladder control.

MS is an autoimmune disease in which the body’s own immune system attacks the protective covering called myelin, that insulate nerve fibers. This myelin sheath enables the brain to communicate with the rest of the body by allowing electrical impulses to travel along the nerve fibers quickly and efficiently. When myelin is damaged, electrical impulses or communication from the brain to the body is slowed or blocked causing MS symptoms.

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How can Medical Marijuana Help Patients with Multiple Sclerosis (MS)?

Much of the data or research collected on the effects of medical marijuana on MS symptoms come from patient surveys, self-reported assessments and observational studies. Two active compounds found in medical marijuana that have been studied in the management of MS include tetrahydrocannabinol (THC) and cannabidiol (CBD).  According to a study published in American Academy of Neurology among patients from the University of Rochester MS Center, results found majority of subjects found medical marijuana helpful in managing symptoms such as spasticity and pain.  The study also reported more than half the subjects felt their quality of life improved with the use of medical marijuana. Another promising study published in 2016 in European Neurology studied patients with treatment-resistant MS spasticity.  Real-life data from the study confirmed that adding THC:CBD oromucosal spray was an effective and well-tolerated treatment option for those patients.

Post-Traumatic Stress Syndrome

A mental health disorder that develops after you experience a traumatic, life-threatening, or highly stressful event.

Post-traumatic stress disorder (PTSD) is a mental health disorder that develops after you experience a traumatic, life-threatening, or highly stressful event.  Examples include sexual assault, war, death of someone close, or a natural disaster.  This is an anxiety disorder that can make it difficult to function to have a “normal” life.  It can last from months to years effecting social relationships, the ability to work and carry out daily tasks like going to the grocery store.  Common symptoms include overwhelming feelings of fear, sadness, anger, hopelessness, or irritability, nightmares, negative outbursts, and being on guard. 

In PTSD, the part of the brain responsible for the “flight-or-fight” response, called the amygdala, becomes overactive. Its job is to heighten our senses to be ready to act during perceived threat.  Another part of the brain that assesses the threat and brings the “flight-or-fight” response down when there is no actual threat is called the prefrontal cortex, and it becomes under-active.

How can Medical Marijuana Help patients with PTSD?

Many patients have reported medical marijuana to help in PTSD. According to an article published by Alcohol and Drug Abuse Institute at University of Washington, anecdotal and case-reports showed evidence marijuana decreased flashbacks, nightmares, anxiety and hyperarousal in PTSD.  A recent trial showed canniboids, an active compound found in medical marijuana, lowered the amygdala’s response and increased the prefrontal cortex response to threat.  Other research has noted participants re-experienced the trauma decreased and had less avoidance of situations that reminded them of the trauma.  These continued reports make medical marijuana an effective treatment for PTSD.

Medical Marijuana As An Alternative Treatment

The Ohio, Pennsylvania, Missouri and Oklahoma Medical Marijuana programs all recognize Spasticity as a qualifying condition for medical marijuana treatment. Emerging research suggests that many patients with conditions such as Cerebral Palsy (CP) or Multiple Sclerosis (MS) might consider cannabis to help relieve symptoms related to spasticity; it’s thought that medical marijuana might calm muscle spasticity. 

What is Spasticity?

Spasticity is a condition associated with damage to the brain, spinal cord or motor nerves, or neurological conditions. Spasticity is increased, involuntary, velocity-dependent muscle tightening that causes resistance to movement. The condition is typically a result of insult to the central nervous system or motor neurons. It may occur as a primary condition such as with degenerative conditions or as a result of secondary causes such as spinal cord injury, trauma to the brain, or inflammatory conditions such as multiple sclerosis.

Spasticity can range from mild feelings of muscle tightness to painful, uncontrollable spasms of extremities, often in the legs, around the joints, and in the lower back. Spasticity patients may experience  symptoms such as: 

• Abnormal posture
• Carrying a shoulder, arm, wrist, and finger at an abnormal angle due to muscle tightness
• Exaggerated deep tendon reflexes (knee-jerk or other reflexes)
• Repetitive jerky motions, especially when touched or moved
• Pain or deformity of the affected area of the body

Spasticity may also affect speech. Severe, long-term spasticity may lead to contracture of muscles. This can reduce range of motion or leave the joints bent.

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